Several strands of research as outlined below.
Mechanism of Mitotic Chromosome Condensation
Mitotic chromosome segregation requires proper chromosome assembly and the phosphorylation of a number of chromosomal proteins. The Aurora B protein kinase and its binding partners INCENP and survivin have a critical role in this process. We are using both biochemical and imaging based approaches to study the function and regulation of the Aurora B protein complex.
Dynamics of the Interphase Nucleus